Chronic alcohol use reshapes the brain's immune landscape, driving anxiety and addiction

(Scripps Research Institute) Deep within the brain, a small almond-shaped region called the amygdala plays a vital role in how we exhibit emotion, behavior and motivation; it's also strongly implicated in alcohol abuse. Now, for the first time, a Scripps Research team has identified important changes to anti-inflammatory mechanisms and cellular activity in the amygdala that drive alcohol addiction.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news

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ConclusionTransient 5-HT inhibition at adolescence may act, in females, as a protective factor for the emergence of anxiety disorders and problematic use of alcohol during adolescence.
Source: Psychopharmacology - Category: Psychiatry Source Type: research
Can people with schizophrenia fall in love? Can they date or even get married? In today’s episode, host Rachel Star Withers (a woman who lives with schizophrenia) and co-host Gabe Howard review their own past romantic experiences. They also interview Andrew and Stephanie Downing, authors of Marriage and Schizophrenia: Eyes on the Prize. Listen to learn about their incredible journey of overcoming schizophrenia and building a healthy, rewarding, and happy marriage. Computer Generated Transcript of “Love, Dating, Marriage with Schizophrenia” Episode Editor’s Note: Please be mindful that this trans...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Inside Schizophrenia Marriage and Divorce Motivation and Inspiration Podcast Relationships Sexuality Source Type: blogs
Abstract The central amygdala (CeA) is a critical regulator of emotional behavior that has been implicated in psychiatric illnesses, including anxiety disorders and addiction. The CeA corticotropin releasing factor receptor 1 (CRF1) system has been implicated in alcohol use disorder (AUD) and mood disorders, and has been shown to regulate anxiety-like behavior and alcohol consumption in rodents. However, the effects of CRF signaling within the CRF receptor 1-containing (CRF1+) population of the CeA remain unclear, and the effects of ethanol and CRF1 manipulations in female rodents have not been assessed. Here, we ...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Neuropharmacology Source Type: research
In conclusion, COVID-19-related distress is common in elite athletes and associated with mental health symptoms. Gambling increase during the pandemic was rare, but related to gambling problems, which were common in male athletes. The calls for increased focus on COVID-19-related concerns in athletes and on problem gambling in male athletes.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
The West Vancouver (Canada) police officer rang the doorbell of my house on Cypress Creek on a fine Tuesday afternoon in April. He told me that a citizen had seen me driving "wildly" the previous Friday afternoon on the Upper Levels Highway and handed me a letter. I thought back to that day. It had started with a large goblet of Chardonnay while making the kids' breakfast. I drove them to school, returned to the house and continued with the white wine. Then I got into the cocaine. Then I was too wired to do anything so I popped a Zopiclone, a tiny blue pill that is guaranteed to put me to sleep ...
Source: PickTheBrain | Motivation and Self Improvement - Category: Consumer Health News Authors: Tags: depression family featured psychology addiction anxiety grief recovery Source Type: blogs
CONCLUSIONS: Our results suggest that the Amazonian medicine-based therapy attracts a diverse patient group not limited to regional residents and may be particularly appealing to more impaired SUD patients with a history of unsuccessful treatment. The sample's cultural diversity suggests an existing interest in such therapies among international SUD treatment-seeking patients. These findings are relevant in light of the need for improved SUD therapies and contribute to the emergent research literature on ayahuasca-based treatments. PMID: 32800077 [PubMed - in process]
Source: Journal of Studies on Alcohol and Drugs - Category: Addiction Tags: J Stud Alcohol Drugs Source Type: research
This study aimed to contribute to this line of research by examining the moderating effect of depression, bipolar spectrum disorder, borderline personality disorder and social anxiety disorder on the association between PBS and alcohol outcomes. Participants (N = 4,960; mean age = 25.43) were young men participating in the Cohort Study on Substance Use Risk Factors. Measures of PBS use, typical drinks per week, alcohol-related consequences, depression, bipolar spectrum disorder, borderline personality disorder and social anxiety disorder were used from the second follow-up assessment. Main results indic...
Source: Addictive Behaviors - Category: Addiction Authors: Tags: Addict Behav Source Type: research
CONCLUSION: We hypothesize that persistent alcohol drinking may contribute to disruption of the normative association between interoception and pain. Future studies should be conducted to develop knowledge on this association and to investigate its possible therapeutic significance and implications. PMID: 32827968 [PubMed - as supplied by publisher]
Source: Addictive Behaviors - Category: Addiction Authors: Tags: Addict Behav Source Type: research
Mikayla Mace A University of Arizona pharmacologist discusses how the conditions created by the pandemic and the response could be exacerbating drug use and overdose. Monday University Communicationssad-505857_1920.jpgHealthCOVID-19Researcher contact: Todd W. Vanderah Comprehensive Pain and Addiction Center 520-626-7801vanderah@email.arizona.eduMedia contact: Mikayla Mace University Communications 520-621-1878mikaylamace@arizona.edu For the latest on the University of Arizona response to the novel coronavirus, visit the university'sCOVID-19 webpage.For UANews coverage of COVID-19, visithttps://uanews.arizona.edu/...
Source: The University of Arizona: Health - Category: Universities & Medical Training Authors: Source Type: research
In this study, our endeavor was to determine if social isolation during adolescence (aSI) was as efficient as MS to facilitate alcohol intake; and moreover, if their combination (MS + aSI) induces even higher alcohol intake and exacerbates anxiety-like behaviors. Also, we evaluated dopamine and endocannabinoid receptors in the NAcc to describe potential changes caused by MS, aSI or both. Wistar rats were reared under 4 different conditions: non-MS + social housing (SH), MS + SH, non-MS + aSI and MS + aSI. Once these rats became adults they were submitted...
Source: Brain Research Bulletin - Category: Neurology Authors: Tags: Brain Res Bull Source Type: research
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