Mixed Outcomes in Tenofovir Trial for Chronic Hepatitis B Mixed Outcomes in Tenofovir Trial for Chronic Hepatitis B

Levels of surface antigen loss were low whether or not patients treated with tenofovir also received interferon, but some patients met criteria for inactive chronic disease after therapy withdrawal.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Gastroenterology News Source Type: news

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Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
Vaccine. 2021 Sep 21:S0264-410X(21)01222-6. doi: 10.1016/j.vaccine.2021.09.031. Online ahead of print.ABSTRACTWorldwide Hepatitis B is known as one of the imperative causes of mortality and morbidity as well as occupational health hazard among health workers. Bangladesh is intermediate endemic country for Hepatitis B infection for which the government has introduced hepatitis B vaccination into the Expanded Programme on Immunization (EPI) nationwide since 2009 for new born children. However, the people who were born before 2009, was dependent on imported hepatitis B vaccine as there was no locally manufactured hepatitis B ...
Source: Vaccine - Category: Allergy & Immunology Authors: Source Type: research
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
Methamphetamine use in adults aged 18 to 64 years increased 43% between 2015 and 2019, astudy in JAMA Psychiatry has found. The study also found that overdose deaths involving psychostimulants other than cocaine, mostly methamphetamine, increased 180% during the same period.Beth Han, M.D., Ph.D., M.P.H., of the National Institute on Drug Abuse (NIDA) and colleagues examined data from 195,711 people who responded to the annual National Survey on Drug Use and Health (NSDUH) between 2015 and 2019. The NSDUH, published by the Substance Abuse and Mental Health Services Administration, is a comprehensive survey of approximately ...
Source: Psychiatr News - Category: Psychiatry Source Type: research
CONCLUSIONS: Ideally, all service members and other at-risk workers should be protected from hepatitis B. This case series suggests that prior non-responders are likely to gain protection from hepatitis B with Heplisav-B vaccination. A prospective trial is warranted for further evaluation of this potential indication.PMID:34557923 | DOI:10.1093/milmed/usab397
Source: Military Medicine - Category: International Medicine & Public Health Authors: Source Type: research
Ann Agric Environ Med. 2021 Sep 16;28(3):458-462. doi: 10.26444/aaem/122627. Epub 2020 Jun 10.ABSTRACTINTRODUCTION: Epidemiological data indicate that one-third of the world's population have serological markers of hepatitis B virus infection. Hepatic steatosis is often observed in patients with chronic liver diseases. The exact mechanisms of hepatic steatosis progression and the efficacy of antiviral therapy in patients with CHB and hepatic steatosis are not yet fully understood.OBJECTIVE: The aim of the study was to investigate the LDLR concentration and degree of hepatic fibrosis and hepatic steatosis in patients with c...
Source: Annals of Agricultural and Environmental Medicine : AAEM - Category: Environmental Health Authors: Source Type: research
e Chronic hepatitis B virus (HBV) infection is a global health problem that can lead to liver dysfunction, including liver cirrhosis and hepatocellular carcinoma (HCC). Current antiviral therapies can control viral replication in patients with chronic HBV infection; however, there is a risk of HCC development. HBV-related proteins may be produced in hepatocytes regardless of antiviral therapies and influence intracellular metabolism and signaling pathways, resulting in liver carcinogenesis. To understand the mechanisms of liver carcinogenesis, the effect of HBV infection in human hepatocytes should be analyzed. HBV inf...
Source: Viruses - Category: Virology Authors: Tags: Review Source Type: research
J Virol Methods. 2021 Sep 20:114295. doi: 10.1016/j.jviromet.2021.114295. Online ahead of print.ABSTRACTCurrent studies focus on cellular and humoral immunity induced by novel SARS-CoV-2 vaccines. Non-responders to vaccinations are not uncommonly encountered in clinical medicine (e.g. in the field of hepatitis B). Whereas vaccine-induced humoral immunity against SARS-CoV-2 is compromised by emerging Variants of Concern (VOCs), cellular immunity against SARS-CoV-2 is emerging as resilient against VOCs. Thus commercially available test kits for diagnostic laboratories designed to evaluate cellular immune responses to SARS-Co...
Source: Journal of Virological Methods - Category: Virology Authors: Source Type: research
Biochem Biophys Res Commun. 2021 Sep 16;578:97-103. doi: 10.1016/j.bbrc.2021.09.028. Online ahead of print.ABSTRACTProteasomal activator 28 gamma (PA28γ) upregulates the levels of HBx, a regulatory protein of hepatitis B virus (HBV) to stimulate HBV replication; however, the detailed mechanism remains unknown. Here, we found that PA28γ impaired the ability of seven in absentia homolog 1 (Siah-1) as an E3 ubiquitin ligase of HBx. PA28γ competitively inhibited the binding of Siah-1 to HBx in human hepatoma cells. Accordingly, PA28γ increased the stability of HBx and decreased HBx ubiquitination, aboli...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Source Type: research
This study aimed to update data on HBV prevalence and reactivation in patients receiving biologic therapy for either chronic rheumatic diseases or IBD, and to describe their management in clinical practice.MATERIALS AND METHODS: This study was performed in 6 Italian centers (3 Rheumatology Units and 3 Gastroenterology Units). Clinical, biochemical and virological data, as well as follow up information, were recorded and analyzed.RESULTS: 984 patients were considered, including 817 with rheumatic disease and 167 with IBD. A total of 43 showed HBV infection (38 OBI and 5 carriers) accounting for a prevalence of 4%. Among OBI...
Source: Annali dell Istituto Superiore di Sanita - Category: General Medicine Authors: Source Type: research
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