The chronic effect of cortisol on orchestrating cerebral blood flow and brain functional connectivity: evidence from Cushing's disease

Cortisol has long been considered to play a crucial role in the pathogenesis of stress-related disorders. Cushing ’s disease (CD) provides an excellent “hyperexpression model” to investigate the chronic effects of cortisol on brain physiology and cognition. Previous studies have shown that cortisol is associated with neurophysiological alterations in animal models, which has also been examined by neural a ctivity and cerebral blood flow (CBF) in human studies. However, the manner in which cortisol affects the coupling between brain activity and metabolic demand remains largely unknown.
Source: Metabolism - Clinical and Experimental - Category: Biomedical Science Authors: Source Type: research