Prostaglandin F2 α in vitro can affect basic inflammatory parameters of mesenchymal stem cells and slight modulating some of their immunomodulatory properties

Mesenchymal stem cells  (MSCs), the major stem cells for cell therapy, have been studied for more than a decade including investigations into their mechanisms of immunoregulatory modulation. The immunomodulatory role of MSCs is well established; MSCs are able to regulate cells involved in adaptive and innate immune resp onses [1], including T and B lymphocytes, natural killer cells, monocytes, macrophages, dendritic cells, and neutrophils [2,3]. These immunomodulatory properties could be used in maintenance of peripheral tolerance, transplantation tolerance, and autoimmunity.

Source: Prostaglandins, Leukotrienes and Essential Fatty Acids - November 13, 2020 Category: Biomedical Science Authors: Andressa Cristina Antunes Santos, Talita Sartori, Primavera Borelli, Ricardo Ambrosio Fock Source Type: research