Tinocordiside from Tinospora cordifolia (Giloy) May Curb SARS-CoV-2 Contagion by Disrupting the Electrostatic Interactions between Host ACE2 and Viral S-Protein Receptor Binding Domain.

CONCLUSION: It indicates that such an interruption of electrostatic interactions between the RBD and ACE2, and the increase in global flexibility of the complex, would weaken or block SARS-CoV-2 entry and its subsequent infectivity. We postulate that natural phytochemicals like Tinocordiside could be the viable options for controlling SARS-CoV-2 contagion and its entry into host cells.
PMID: 33172372 [PubMed - as supplied by publisher]

Source: Combinatorial Chemistry and High Throughput Screening - November 10, 2020 Category: Chemistry Authors: Balkrishna A, Pokhrel S, Varshney A Tags: Comb Chem High Throughput Screen Source Type: research