Population-based meta-analysis of chloroquine: informing chloroquine pharmacokinetics in COVID-19 patients

ConclusionModel-based simulation using PK parameters from the COVID-19 patients shows that the concentrations under the currently recommended dosing regimen are below the safety margin for side-effects, which suggests that these dosing regimens are generally safe. The derived population PK model should allow for the assessment of pharmacokinetics –pharmacodynamics (PK-PD) relationships for CQ when given alone or in combination with other agents to treat COVID-19.
Source: European Journal of Clinical Pharmacology - Category: Drugs & Pharmacology Source Type: research