Heat shock transcription factor 2 reduces the secretion of IL-1 β by inhibiting NLRP3 inflammasome activation in ulcerative colitis.

In this study, hsf-/- DSS model mice showed highest levels of expression of the NLRP3 inflammasome and the secretion of IL-1β. In Caco-2 cells, the levels of expression of the NLRP3 inflammasome and the secretion of IL-1β were inhibited by overexpression of HSF2, and inhibited HSF2 increased activation of the NLRP3 inflammasome and the secretion of IL-1β. These findings indicated that HSF2 might be an important target for inflammatory modulation in UC.
PMID: 33181254 [PubMed - as supplied by publisher]

Source: Gene - November 9, 2020 Category: Genetics & Stem Cells Authors: Zhang F, Zhao W, Zhou J, Wang W, Luo J, Feng Y, Wu J, Li M, Wang K, Niu J, Miao Y Tags: Gene Source Type: research