New insights into the function of mammalian Argonaute2

by Marek Marzec Uncovering the mechanisms that recognise a microRNA (miRNA) target is 1 of the biggest challenges because the Ago–miRNA complex is able to overcome different derogations of complementarity when binding targets. However, the recently solved crystallographic structure of Argonaute2 (Ago2) and a hi gh-throughput analysis that used repurposed sequencing techniques has brought us closer to achieving this goal.
Source: PLoS Genetics - Category: Genetics & Stem Cells Authors: Source Type: research
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