Interaction of flavonoids with serum albumin: A review.

Interaction of flavonoids with serum albumin: A review.
Curr Protein Pept Sci. 2020 Nov 08;:
Authors: Xue P, Zhang G, Zhang J, Ren L
Abstract
Flavonoids are plant products abundant in every day diet and claimed to be beneficial for human health. After absorption, flavonoids are transported by the serum albumin (SA), the most abundant carrier blood protein, through formation of flavonoids-SA complex. This review deals with the current state of knowledge on flavonoids-SA complex over the past 10 years, mainly involved multi-spectroscopic techniques and molecular dynamics simulation studies to explore the binding mechanism, thermodynamics and structural aspects of flavonoids binding to SA. Especially, the novel method, capillary electrophoresis, high performance affinity chromatography approach, native mass spectrometry and microscale thermophoresis used in characterization of the interaction between flavonoids and SA as well as flavonoid-based fluorescent probe for SA measurement are also included in this review.
PMID: 33167830 [PubMed - as supplied by publisher]

Source: Current Protein and Peptide Science - November 8, 2020 Category: Biochemistry Authors: Xue P, Zhang G, Zhang J, Ren L Tags: Curr Protein Pept Sci Source Type: research