Daily drinking increases risk of alcoholic cirrhosis

(Elsevier Health Sciences) Approximately 170,000 people die from alcoholic cirrhosis of the liver in Europe every year. Although alcohol is the most important risk factor, less is known about the significance of different patterns of drinking. Currently scientists believe that cirrhosis is a function of the volume of alcohol consumed irrespective of patterns of drinking. Investigators have now established that alcohol drinking pattern has a significant influence on the risk of cirrhosis and that daily drinking increases that risk compared with drinking less frequently.
Source: EurekAlert! - Social and Behavioral Science - Category: Global & Universal Source Type: news

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CONCLUSION: the proportion of admissions due to decompensated HCV-related cirrhosis has decreased by almost 30 % since the introduction of the DAA. In addition, the characteristics of patients admitted have changed since the application of interferon-free regimens. PMID: 32496126 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research
We described the risk of hepatocellular carcinoma (HCC, the commonest form of liver cancer originating in the liver) in Danish outpatients with liver cirrhosis due to harmful alcohol consumption. Accurate data on that risk are important for patient counselling and decisions about screening for HCC. The risk was about 0.7% per year, which is lower than might be expected and suggests that many potentially harmful screening examinations are required for every HCC found through surveillance.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research
Background and aim: Cirrhosis is a major public health problem worldwide. The prevalence of cirrhosis is various in different geographical regions. The aim of the present study was to determine the distribution of the etiologies of cirrhosis and their proportional changes through recent 11 years in Iran. Methods: In this retrospective, observational study, the data of cirrhotic patients who have been listed for liver transplantation in the Namazi Transplant Center (Shiraz, Iran) between January 2006 and December 2016 were analyzed. Demographic and clinical data of the patients including model for end-stage liver disea...
Source: European Journal of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Original Articles: Hepatology Source Type: research
Basel, 2 June 2020 – Roche (SIX: RO, ROG; OTCQX: RHHBY) today announced that the US Food and Drug Administration (FDA) has approved Tecentriq® (atezolizumab) in combination with Avastin® (bevacizumab) for the treatment of people with unresectable or metastatic hepatocellular carcinoma (HCC) who have not received p rior systemic therapy.“We’re excited that today’s approval of Tecentriq in combination with Avastin for unresectable or metastatic hepatocellular carcinoma brings a cancer immunotherapy option to people with this aggressive form of liver cancer,” said Levi Garraway, M.D., Ph....
Source: Roche Media News - Category: Pharmaceuticals Source Type: news
A 58-year-old woman with history of alcohol-associated Child-Pugh class C cirrhosis (MELD 11) complicated by portal hypertension, ascites, encephalopathy, and non-bleeding esophageal varices presented with biliary obstruction, biloma, and high-output percutaneous biliary drainage. She had an enlarging, 1.9-cm, enhancing LIRADS-4 liver lesion (in segment 4A) and underwent CT-guided percutaneous microwave ablation 2 years ago. Ablation was successful but complicated by a recurrent abscess/biloma in the left liver that required a percutaneous transhepatic biliary drain that could not be internalized due to lack of communicati...
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Oral abstracts Source Type: research
This study examined the ability of elastography by endoscopic ultrasound to predict histologic fibrosis in patients with NASH and compared it with standard magnetic resonance techniques.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Oral abstracts Source Type: research
co Giannini Hepatocellular carcinoma (HCC), the most frequent primary liver cancer, is the sixth most common cancer, the fourth leading cause of cancer-related deaths worldwide, and accounts globally for about 800,000 deaths/year. Early detection of HCC is of pivotal importance as it is associated with improved survival and the ability to apply curative treatments. Chronic liver diseases, and in particular cirrhosis, are the main risk factors for HCC, but the etiology of liver disease is rapidly changing due to improvements in the prevention and treatment of HBV (Hepatitis B virus) and HCV (Hepatitis C virus) infect...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
In conclusion, propranolol is associated with decreased risk of HCC incidence in patients with AC. PMID: 32454812 [PubMed - as supplied by publisher]
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
AbstractAlcohol ‐induced liver disease (ALD) is one of the major causes of chronic liver disease globally. The pathogenesis of alcohol‐induced hepatic injury is characterized by steatosis, inflammation and fibrosis, which can eventually progress to cirrhosis and hepatocellular carcinoma1). Recently, the mechanism of both ALD and non ‐alcoholic fatty liver disease (NAFLD) has been fairly well studied, but a successful treatment for ALD and NAFLD is not available yet.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: COMMENTARY Source Type: research
Conclusions: Our results confirm the efficacy of the liver transplantation to achieve of a good QOL. Furthermore, these patients seem to maintain high therapeutic adherence, thus ensuring a good outcome of the care received during the transplantation process.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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