Cardioprotective effects of natural products via the Nrf2 signaling path-way.

Cardioprotective effects of natural products via the Nrf2 signaling path-way. Curr Vasc Pharmacol. 2020 Nov 03;: Authors: Tavakoli R, Tabeshpour J, Asili J, Shakeri A, Sahebkar A Abstract Due to its poor regenerative capacity, the heart is specifically vulnerable to xenobiotic-induced cardiotoxicity, myocardial ischaemia/reperfusion injury and other pathologies. Nuclear factor erythroid-2-related factor 2 (Nrf2) is consid-ered as an essential factor in protecting cardiomyocytes against oxidative stress resulting from free radicals and reactive ox-ygen species. It also serves as a key regulator of antioxidant enzyme expression via the antioxidant response element, a cis-regulatory element, which is found in the promoter region of several genes encoding detoxification enzymes and cytoprotec-tive proteins. It has been reported that a variety of natural products are capable of activating Nrf2 expression, and in this way, increase the antioxidant potential of cardiomyocytes. In the present review, we consider the cardioprotective activities of natural products and their possible therapeutic potential. PMID: 33155913 [PubMed - as supplied by publisher]
Source: Current Vascular Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Curr Vasc Pharmacol Source Type: research