Antischistosomal properties of aurone derivatives against juvenile and adult worms of Schistosoma mansoni.

Antischistosomal properties of aurone derivatives against juvenile and adult worms of Schistosoma mansoni. Acta Trop. 2020 Nov 04;:105741 Authors: Pereira VRD, da Silveira LS, Mengarda AC, Júnior IJA, da Silva OOZ, Miguel FB, Silva MP, Almeida ADC, da Silva Torres D, Pinto PF, Coimbra ES, de Moraes J, Couri MRC, da Silva Filho AA Abstract Schistosomiasis is a neglected disease caused by helminth flatworms of the genus Schistosoma, affecting over 240 million people in more than 70 countries. The treatment relies on a single drug, praziquantel, making urgent the discovery of new compounds. Aurones are a natural type of flavonoids that display interesting pharmacological activities, particularly as chemotherapeutic agents against parasites. In pursuit of treatment alternatives, the present work conducted an in vitro and in vivo antischistosomal investigation with aurone derivatives against Schistosoma mansoni. After preparation of aurone derivatives and their in vitro evaluation on adult schistosomes, the three most active aurones were evaluated in cytotoxicity and haemolytic assays, as well as in confocal laser-scanning microscope studies, showing tegumental damage in parasites in a concentration-dependent manner with no haemolytic or cytotoxic potential toward mammalian cells. In a mouse model of schistosomiasis, at a single oral dose of 400 mg/kg, the selected aurones showed worm burden reductions of 35% to 65.0% and egg reductions...
Source: Acta Tropica - Category: Infectious Diseases Authors: Tags: Acta Trop Source Type: research