Kinetic Modelling and Test –Retest Reproducibility for the Dopamine D 1 R Radioligand [ 11 C]SCH23390 in Healthy and Diseased Mice

ConclusionsNinety-minute acquisition and the use of SRTM for pharmacokinetic modelling is recommended. [11C]SCH23390 PET imaging demonstrates optimal characteristics for the study of dopamine D1R density in models of psychiatric and neurological disorders as exemplified in the Q175DN mouse model of HD.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research