Enhanced expression of ACE2 in psoriatic skin and its upregulation in keratinocytes by interferon-gamma: Implication of inflammatory milieu in skin tropism of SARS-CoV-2.

Enhanced expression of ACE2 in psoriatic skin and its upregulation in keratinocytes by interferon-gamma: Implication of inflammatory milieu in skin tropism of SARS-CoV-2.
Br J Dermatol. 2020 Nov 06;:
Authors: Tembhre MK, Parihar AS, Sharma VK, Imran S, Bhari N, Lakshmy R, Bhalla A
Abstract
The novel coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a challenging situation globally due to its contagion nature. SARS-CoV-2 enters the host cell by interacting with the ACE2 (angiotensin converting enzyme 2) receptor present on cell surface through its receptor-binding domain (RBD) of spike protein (1). Host proteases mainly TMPRSS2 plays a vital role in cleaving the SARS-CoV-2 spike protein thereby enabling the virus to enter host cell via endocytosis. SARS-CoV-2 mainly affects the respiratory system of the infected host, however, its manifestation to other organs have also been reported (2).
PMID: 33155280 [PubMed - as supplied by publisher]

Source: The British Journal of Dermatology - November 6, 2020 Category: Dermatology Authors: Tembhre MK, Parihar AS, Sharma VK, Imran S, Bhari N, Lakshmy R, Bhalla A Tags: Br J Dermatol Source Type: research