Short-term mortality in patients with cirrhosis of the liver and acute kidney injury: A prospective observational study

ConclusionDevelopment of AKI as defined by the International Ascites Club in cirrhosis confers high short-term mortality. Jaundice, HE, AKI stage, creatinine at enrollment, bilirubin, CTP, and MELD score were the predictors of mortality.Bullet points of the study highlightsWhat is already known?• Renal failure is a common and severe complication of cirrhosis.• Serum creatinine is the most practical biomarker of renal function but it has many limitations in cirrhotic patients.• Creatinine kinetics–based definition of acute kidney injury (AKI) was proposed by the International Ascites Club.What is new in this study?• Short-term mortality (30 days) in decompensated cirrhotic patients with AKI as defined by the International Ascites Club using creatinine kinetics was high.• AKI due to hepatorenal syndrome (HRS) has the highest short-term (30 days) mortality followed by AKI due to infection in decompensated cirrhosis.• Detection of AKI using creatinine kinetics–based definition may prompt an early appropriate intervention.What are the future clinical and research implications of study findings?• Creatinine kinetics–based definition of AKI diagnose renal injury at an earlier stage; an appropriate intervention should be initiated at the earliest in these patients to improve patient survival.
Source: Indian Journal of Gastroenterology - Category: Gastroenterology Source Type: research