A Pilot Trial of Platelets Stored Cold versus at Room Temperature for Complex Cardiothoracic Surgery

ConclusionsThis pilot trial supports the feasibility of platelets stored cold for up to 14 days and provides critical guidance for future pivotal trials in high-risk cardiothoracic bleeding patients.Editor ’s PerspectiveWhat We Already Know about This TopicPlatelets are stored at room temperature (20 ° to 24°C) with constant agitation for 5 to 7 days to maximize recovery and survivalin vivo after transfusionCold storage of platelets at 2 ° to 6°C would provide extended shelf life, and laboratory investigations indicate improved hemostatic function, which may be beneficial for treatment of bleedingWhat This Article Tells Us That Is NewNo significant difference was observed between cold-stored and room temperature –stored platelets for hemostatic function assessed by chest drainage, total blood usage, platelet function, and clinical outcomesThis pilot trial supports the potential feasibility of cold-stored platelets for clinical use and provides potential guidance for future pivotal trials
Source: Anesthesiology - Category: Anesthesiology Source Type: research