Acid-sensing Ion Channel 3 Overexpression in Incisions Regulated by Nerve Growth Factor Participates in Postoperative Nociception in Rats

ConclusionsAcid-sensing ion channel 3 overexpression in incisions contributes to postoperative guarding and mechanical nociception. Bidirectional transport of ASIC3 between incised tissues and dorsal root ganglion neurons occurs through the sciatic nerve. Nerve growth factor regulates ASIC3 expression after plantar incision through the phosphoinositide 3 –kinase/protein kinase B signaling pathway.Editor ’s PerspectiveWhat We Already Know about This TopicThe low pH of surgical wounds contributes to postoperative painAcid-sensing ion channels such as acid-sensing ion channel 3 are structures that sensitize nociceptive neurons after soft tissue incisionWhat This Article Tells Us That Is NewUsing a rat model of surgical incision, it was shown that both male and female animals demonstrated less wound area sensitization when acid-sensing ion channel 3 channels were pharmacologically blocked or knocked down using small interfering RNAAnti –nerve growth factor treatment blocked the upregulation of acid-sensing ion channel 3 expression after incision and reduced the pain-related behaviors

Source: Anesthesiology - November 11, 2020 Category: Anesthesiology Source Type: research