Ketamine Pharmacokinetics A Systematic Review of the Literature, Meta-analysis, and Population Analysis

ConclusionsA meta-analytical analysis of ketamine pharmacokinetics was successfully completed despite large heterogeneity in study characteristics. Differences in output of the meta-analytical approach and a combined analysis of 14 raw data sets were small, indicative that the meta-analytical approach gives a clinically applicable approximation of ketamine population parameter estimates and may be used when no raw data sets are available.Editor ’s PerspectiveWhat We Already Know about This TopicThere has been a renewed interest in ketamine because of potentially new indicationsA broad range of models have been published to describe ketamine pharmacokinetics in different populations and after different methods of administration and blood samplingA general pharmacokinetic model could greatly aid in the development of dosing schemes that maximize therapeutic effects while minimizing side effectsWhat This Article Tells Us That Is NewA meta-analysis was successfully performed on 18 studies that had conducted mixed-effect pharmacokinetic analyses despite large heterogeneity in study characteristicsA populations pharmacokinetic analysis was performed on raw data sets obtained from 14 unique sourcesParameter estimates in the population pharmacokinetic analysis were comparable with those obtained in the meta-analysis of three-compartment pharmacokinetic models
Source: Anesthesiology - Category: Anesthesiology Source Type: research