Polarization of ADAM17-driven EGFR signalling in electric field-guided collective migration of epidermal sheets.

In conclusion, our study indicated that ADAM17 contributed to the collective directional movement of the epidermal monolayer by driving HB-EGF release and activating EGFR under EFs, and this pathway also mediated the polarization of F-actin in migrating sheets, which is essential in directional migration.
PMID: 33164313 [PubMed - as supplied by publisher]

Source: J Cell Mol Med - November 8, 2020 Category: Molecular Biology Authors: Jia N, Liu J, Zhu G, Liang Y, Wang Y, Wang W, Chen Y, Yang J, Zhang W, Zhang J Tags: J Cell Mol Med Source Type: research