Synaptic Basis of Alzheimer's Disease: Focus on Synaptic Amyloid Beta, P-Tau and Mitochondria.

This article addresses the mechanisms of synaptic action, mitochondrial regulation/dysregulation, resulting synaptic changes caused by amyloid beta and phosphorylated tau in AD progression. This article also highlights recent developments of risk factors, genetics and ApoE4 involvement, factors related to synaptic damage and loss, mislocalization of amyloid beta and phosphorylated tau, mitophagy, microglial activation and synapse-based therapies in AD. Furthermore, impairments in LTD and reactivation of microglia are discussed. PMID: 33157321 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33157321?dopt=Abstract

Source: Ageing Research Reviews - November 3, 2020 Category: Genetics & Stem Cells Authors: John A, Reddy PH Tags: Ageing Res Rev Source Type: research