Alcohol-related context modulates neural correlates of inhibitory control in alcohol dependent patients: preliminary data from an fMRI study using an alcohol-related Go/NoGo-task.

Alcohol-related context modulates neural correlates of inhibitory control in alcohol dependent patients: preliminary data from an fMRI study using an alcohol-related Go/NoGo-task. Behav Brain Res. 2020 Nov 03;:112973 Authors: Stein M, Steiner L, Fey W, Conring F, Rieger K, Andrea F, Moggi F Abstract Alcohol use disorder (AUD) is characterized by both impaired inhibitory control and heightened cue reactivity, including enhanced craving and drinking urges in response to alcohol-related stimuli. The interaction between these two mechanisms is thought to be crucial in the maintenance of addiction and relapse. The present study used a newly developed alcohol-related Go/NoGo-task to investigate how exposure to alcohol-related cues affects neural processing of inhibitory control in subjects with AUD. Functional magnetic resonance imaging (fMRI) was recorded during performance of a Go/NoGo task, which incorporated alcohol-related and neutral stimuli as Go and NoGo trials in abstinent AUD patients and healthy controls (HC). AUD patients exhibited increased activation of a fronto-striatal-parietal network during successful response inhibition relative to HC. Within the AUD group, activation for alcohol-related (relative to neutral) inhibition was enhanced in regions including bilateral anterior cingulate cortex (ACC), right medial frontal and precentral gyri, and right putamen. Activation differences in the right ACC increased with subjective ...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research