Antidiabetic effect of Pistacia atlantica and Amygdalus scoparia in streptozotocin-induced diabetic mice

Abstract Diabetes mellitus (DM) is a growing health concern worldwide. Many traditional treatments have been recommended in the alternative system of medicine for treatment of DM. Pistacia atlantica and Amygdalus scoparia have a long history as a medicinal plant since the ancient times. The present study evaluated the differential effects of N-hexane extraction of these plants on the blood glucose concentration and the pathology of the pancreas in diabetic mice. DM was induced in 40 out of 50 adult female mice, using intraperitoneal injection of 60 mg/kg BW streptozotocin. The diabetic mice were assigned into four groups, three of which were treated with extract of garlic and P. atlantica, A. scoparia, and glibenclamide (200 mg/kg) for 15 days and the mice of the fourth group, as the untreated group, received ordinary diet. Ten nondiabetic mice remained as the normal control group. The results of this study indicate that these plants were able to reduce blood glucose significantly compared with the control diabetic group (P 
Source: Comparative Clinical Pathology - Category: Pathology Source Type: research

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Publication date: November 2019Source: Chinese Journal of Analytical Chemistry, Volume 47, Issue 11Author(s): Wei-Feng LI, De-Wen YAN, Yu JIN, Hai-Yan LI, Min MA, Zheng-Zhi WUAbstractDiabetes mellitus (DM) is a metabolic disorder disease characterized by hyperglycemia. Long-term physiological hyperglycemia will aggravate the degree of non-enzymatic glycation (NEG) proteins. Because the abnormal changes of non-enzymatic process can cause a series of pathological variation, NEG proteins have attracted more and more attention. Mass spectrometry (MS) is an indispensable and powerful analytical tool for the qualitative and quan...
Source: Chinese Journal of Analytical Chemistry - Category: Chemistry Source Type: research
This study aimed to evaluate long-term patency of the RA conduit compared to the SV conduit for off-pump CABG, and to screen the independent predictors of long-term RA graft failure.Patients
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
This study investigated the impact of including fetal growth parameters in the monitoring of pregnant women with type 1 diabetes mellitus. Patients/Method 199 pregnant women with type 1 DM were included in a cohort study. The patient population was divided into two study cohorts. In the mBG cohort (n = 94; investigation period: 1994 - 2005) treatment was monitored using only maternal blood glucose (mBG) values; the aim was to achieve standard target glucose values (mean BG
Source: Geburtshilfe und Frauenheilkunde - Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research
Condition:   Diabetes Mellitus, Type 2 Intervention:   Other: Oral Nutrition Supplement Sponsor:   Nestlé Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Gestational Diabetes Interventions:   Behavioral: New Nordic Diet;   Other: Control Sponsors:   Göteborg University;   Swedish research council for health, working life and welfare Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Stojanovic D, Mitic V, Petrovic D, Stojanovic M, Ignjatovic A, Stefanovic N, Cvetkovic T, Bojanic V, Kocic G, Ilic MD Abstract Heart failure represents a growing health problem, with increasing morbidity and mortality globally. According to the mechanisms involved in the pathogenesis of heart failure, many biomarkers have been proposed for the timely diagnosis and prognostication of patients with heart failure, but other than natriuretic peptides, none of them has gained enough clinical significance. Renalase, a new protein derived from kidneys was demonstrated to metabolize catecholamines and to have a ca...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Conclusion: This study showed that smoking was closely associated with liver fibrosis among the patients with NAFLD. For patients with NAFLD who smoke, priority screening and timely intervention should be provided if they are at risk of liver fibrosis. PMID: 31737583 [PubMed - in process]
Source: Canadian Journal of Gastroenterology - Category: Gastroenterology Tags: Can J Gastroenterol Hepatol Source Type: research
AbstractPurpose of ReviewThis review intends to highlight selected cardiovascular disease (CVD) prevention studies presented at the 2019 European Society of Cardiology (ESC) Congress.Recent FindingsResults from the Inclisiran for Subjects with ASCVD or ASCVD-risk Equivalent and Elevated Low-density Lipoprotein Cholesterol (ORION-11) trial validate inclisiran ’s ability to significantly lower low-density lipoprotein cholesterol (LDL-C) levels in at-risk individuals on a background of maximally tolerated statin therapy. The EVOlocumab for Early Reduction of LDL-cholesterol Levels in Patients With Acute Coronary Syndrom...
Source: Current Atherosclerosis Reports - Category: Cardiology Source Type: research
Conclusions: The higher prevalence of elevated FG and/or T2DM among Roma does not seem to be directly linked to their increased genetic load but rather to their environmental/cultural attributes. Interventions targeting T2DM prevention among Roma should focus on harmful environmental exposures related to their unhealthy lifestyle.
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
Conclusion: In a representative Brazilian population of T1DM patients, those with IDAA1c ≤ 9 presented a lower frequency of MC, as well as fewer episodes of hypoglycemia, in the month prior to the analysis.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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