Cancer classification based on chromatin accessibility profiles with deep adversarial learning model
In this study, based on the deep adversarial learning, we present an end-to-end approach ClusterATAC to leverage high-dimensional features and explore the classification results. On the ATAC-seq dataset and RNA-seq dataset, ClusterATAC has achieved exc ellent performance. Since ATAC-seq data plays a crucial role in the study of the effects of non-coding regions on the molecular classification of cancers, we explore the clustering solution obtained by ClusterATAC on the pan-cancer ATAC dataset. In this solution, more than 70% of the clustering are single-tumor-type-dominant, and the vast majority of the remaining clusters are associated with similar tumor types. We explore the representative non-coding loci and their linked genes of each cluster and verify some results by the literature search. These results suggest that a large number of non -coding loci affect the development and progression of cancer through its linked genes, which can potentially advance cancer diagnosis and therapy.
Source: PLoS Computational Biology - Category: Biology Authors: Hai Yang Source Type: research
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