Association of the Sp1 binding site and -1997 promoter variations in COL1A1 with osteoporosis risk: The application of meta-analysis and bioinformatics approaches offers a new perspective for future research

Publication date: October–December 2020Source: Mutation Research/Reviews in Mutation Research, Volume 786Author(s): Shirin Moradifard, Moslem Hoseinbeyki, Mohammad Mehdi Emam, Fatemehsadat Parchiniparchin, Mina Ebrahimi-Rad
Source: Mutation Research Reviews in Mutation Research - Category: Genetics & Stem Cells Source Type: research

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CONCLUSIONS: Alen-NDs can be used as potential therapeutic agents for osteoporosis treatment by inducing osteogenic differentiation.PMID:34556181 | DOI:10.1186/s40824-021-00231-9
Source: Cell Research - Category: Cytology Authors: Source Type: research
Cytokine. 2021 Sep 21;148:155708. doi: 10.1016/j.cyto.2021.155708. Online ahead of print.ABSTRACTOBJECTIVE: The purpose of this study was to evaluate the role of circulating serum levels of irisin in predicting hip fracture occurrence in a cohort of Chinese postmenopausal women.METHODS: This was a cross-section and case-control study. Four hundred and thirty postmenopausal women aged 50-90 years were included (215 with hip fractures and 215 age-matched cases without fracture). Clinical features, bone mineral density (BMD) and serum biomarkers levels including irisin were measured at baseline. Cox proportional hazards regre...
Source: Cytokine - Category: Molecular Biology Authors: Source Type: research
CONCLUSIONS The findings showed that TiRobot-assisted sacroiliac screw fixation and bone grafting was a safe and effective surgical treatment option that had a reduced radiation dose and improved fracture healing, when compared with standard screw fixation without bone grafting.PMID:34556623 | DOI:10.12659/MSM.932724
Source: Medical Science Monitor - Category: Research Authors: Source Type: research
CONCLUSIONS: BF4 is a potent and selective inhibitor of PC1/3.GENERAL SIGNIFICANCE: BF4 is the best candidate for further clinical studies on inhibition of PC1/3.PMID:34560176 | DOI:10.1016/j.bbagen.2021.130016
Source: Biochimica et Biophysica Acta - Category: Biochemistry Authors: Source Type: research
CONCLUSION: QG could accelerate osteoporotic fracture healing by promoting bone formation and osteocyte autophagy, possibly through upregulating the NF-κB/HIF-1α signaling pathway.PMID:34557256 | PMC:PMC8455191 | DOI:10.1155/2021/9943692
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Source Type: research
Osteoclasts (OCs) play an important role in osteoporosis, a disease that is mainly characterized by bone loss. In our research, we aimed to identify novel approach for regulating osteoclastogenesis and thereby treating osteoporosis. Previous studies have set a precedent for screening traditional Chinese herbal extracts for effective inhibitors. Peiminine is an alkaloid extracted from the bulb of Fritillaria thunbergii Miq that reportedly has anticancer and anti-inflammatory effects. Thus, the potential inhibitory effect of peiminine on OC differentiation was investigated via a series of experiments. According to the result...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Conclusion: SSTZF-NB enhances osteogenesis mainly via activation of β-catenin signaling in growth plate chondrocytes. SSTZF-NB is the optimal anti-osteoporosis fraction of SSTZF and it can be considered a salutary alternative therapeutic option for osteoporosis.
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionHealthcare professionals are encouraged to apply recommendations presented in this scoping review in their clinical practice. Patient understanding of risk of fracture should be confirmed by making sure that patients feel free to ask questions and express their concerns. This will contribute to an optimal patient-centered approach. Developing online tools to convert the probability of fracture into patient-friendly visual presentations could facilitate communication between healthcare professionals and patients about risk of fracture.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
AbstractSummaryBone turnover markers are decreased in GC-treated subjects with DM. Decreased OC levels in GC-treated patients were associated with an increased risk of DM. These results suggest the involvement of OC in glucose homeostasis regulation in DM.IntroductionOsteocalcin (OC) is involved in the regulation of glucose homeostasis. Glucocorticoid (GC) treatment is associated with impaired osteoblast function, decreased OC levels, and the development and/or worsening of pre-existing diabetes mellitus (DM). Whether decreased OC levels in GC-treated subjects contribute to DM is not well known. The aim of this study was t...
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
J Clin Endocrinol Metab. 2021 Sep 23:dgab696. doi: 10.1210/clinem/dgab696. Online ahead of print.ABSTRACTCONTEXT: Fracture-on-therapy should motivate better anti-fracture medication adherence.OBJECTIVE: Describe osteoporosis medication adherence in women before and following a fracture.DESIGN: Retrospective cohort study.SETTING: Manitoba BMD Registry (1996-2013).PATIENTS: Women who started anti-fracture drug therapy after a DXA-BMD with follow-up for 5 years during which a non-traumatic fracture occurred at least one year after starting treatment.MAIN OUTCOME: Linked prescription records determined medication adherence (es...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Source Type: research
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