Putative protective role of autoantibodies against the insulin-like growth factor-1 receptor in Graves ’ Disease: results of a pilot study

ConclusionsIGF-1RAbs appear to be greater in patients with GD without GO compared with those with GO, suggesting a putative protective role of IGF-1RAbs on the development of GO, in line with the beneficial effects of Teprotumumab on GO. The inverse correlation between IGF-1RAbs and TRAbs 6  months after radioiodine may reflect antigen spreading and/or GC treatment.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research