New method developed by Lithuanian scientists can reach 90% accuracy in detecting melanoma

(Kaunas University of Technology) A team of researchers from Kaunas University of Technology and Lithuanian University of Health Sciences proposed a non-invasive method for detection of melanoma. A patented computer-aided diagnostic system developed by Lithuanian scientists proved to be more than 90% accurate in detecting malignancy in diagnostic images of skin lesions acquired from 100 patients.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Each year, as Memorial Day approaches, Holly Thaggard braces herself for the headlines. About how sunscreen may be damaging coral reefs. About the possible flammability of spray-on sunscreen. Headlines—as there were this year—about how sunscreen contains chemicals that could harm your health. “This has happened every single year for the last decade of my life,” says Thaggard, founder of Texas-based Supergoop, a sunscreen company that brands itself as reef-safe and free of hundreds of potentially problematic ingredients. This year, the is-sunscreen-dangerous news cycle started in May, when Valisure, ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthscienceclimate Public Health Source Type: news
CONCLUSIONS: This review summarizes the effects of UVB (280-315 nm) and UVA (315-400 nm) radiation on the Nrf2 signalling pathway in dermal fibroblasts and epidermal keratinocytes and melanocytes. The effects of natural compounds (pure compounds or mixtures) on Nrf2 activity and level as well as on Nrf2-driven genes in UV irradiated human skin fibroblasts, keratinocytes and melanocytes are briefly mentioned as well.HighlightsUVB radiation is a rather poor activator of the Nrf2-driven pathway in fibroblastsUVA radiation stimulates Nrf2 activation in dermal fibroblastsEffects of UVA on the Nrf2 pathway in keratinocytes and m...
Source: International Journal of Radiation Biology - Category: Radiology Authors: Source Type: research
Conclusions: Three HPN-LMS genes (ARRDC3, NYNRIN, RND3) associated with longer survival in SKCM and/or UVM patients exhibited strong anti-invasion activity in human melanoma cells, consistent with roles as effectors of the metastasis suppressor functions of Nme1 and Nme2. The HP/HPN mouse paradigm has thus yielded a network of potential therapeutic targets and prognostic markers for clinical management of metastatic melanoma.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Contributors : Parmanand Malvi ; Narendra WajapeyeeSeries Type : Expression profiling by arrayOrganism : Homo sapiensPhosphoserine phosphatase (PSPH) has been shown to be important for progression of several tumors. PSPH expression is elevated in multiple cancer types including cutaneous melanoma. Therefore, we analyzed the role of PSPH in melanoma. Inhibition of PSPH in melanoma cell lines resulted in decreased proliferation, decreased invasion, and increased cell death. PSPH expression is regulated through MAP kinase pathway and inhibition of MAPK pathway leads to diminished PSPH expression.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
Contributors : Parmanand Malvi ; Narendra WajapeyeeSeries Type : Expression profiling by arrayOrganism : Homo sapiensAcid ceramidase (ASAH1) has been shown to be important for progression of several tumors. ASAH1 expression is elevated in multiple cancer types including cutaneous melanoma. Therefore, we analyzed the role of ASAH1 in melanoma. Inhibition of ASAH1 in melanoma cell lines resulted in decreased proliferation, and increased cell death. ASAH1 expression is regulated through MAP kinase pathway and inhibition of MAPK pathway leads to diminished ASAH1 expression.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Homo sapiens Source Type: research
AbstractCutaneous melanoma remains a severe public health threat, with annual incidence increasing slowly but steadily over 4 decades. While early-stage melanomas can typically be treated with complete surgical excision with favorable results, the development of metastatic cancer, which is related to a lower survival rate, is linked to the primary tumor's rising stage and other high-risk features. Even though the first discoveries of an immunological anti-tumor response were published about a century ago, immunotherapy has only been a feasible therapeutic option for cutaneous melanoma in the last 30  years. Nonetheles...
Source: Dermatology and Therapy - Category: Dermatology Source Type: research
Cancer Gene Therapy, Published online: 02 August 2021; doi:10.1038/s41417-021-00367-9Enhanced antitumor immune response in melanoma tumor model by anti-PD-1 small interference RNA encapsulated in nanoliposomes
Source: Cancer Gene Therapy - Category: Cancer & Oncology Authors: Source Type: research
Source: Anti-Cancer Agents in Medicinal Chemistry - Category: Cancer & Oncology Authors: Tags: Research article Source Type: research
This study aimed to determine the association between: (i) cognitive decline and bone loss; and (ii) clinically significant cognitive decline on Mini Mental State Examination (MMSE) over the first 5 years and subsequent fracture risk over the following 10 years. A total of 1741 women and 620 men aged ≥65 years from the population-based Canadian Multicentre Osteoporosis Study were followed from 1997 to 2013. Over 95% of participants had normal cognition at baseline. After multivariable adjustment, cognitive decline was associated with bone loss in women but not men. Approximately 13% of participants ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Eur J Pharmacol. 2021 Jul 29:174397. doi: 10.1016/j.ejphar.2021.174397. Online ahead of print.ABSTRACTAccumulating evidence shows that deregulation of fatty acid (FA) metabolism is associated with the development of cancer. Long-chain acyl-coenzyme A synthases (ACSLs) are responsible for activating long-chain FAs and are frequently deregulated in cancers. Among the five mammalian ACSL family members, ACSL1 is involved in the TNFα-mediated pro-inflammatory phenotype and mainly facilitates cancer progression. ACSL3 is an androgen-responsive gene. High ACSL3 expression has been detected in a variety of cancers, includin...
Source: European Journal of Pharmacology - Category: Drugs & Pharmacology Authors: Source Type: research
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