HMGB1 released from GSDME-mediated pyroptotic epithelial cells participates in the tumorigenesis of colitis-associated colorectal cancer through the ERK1/2 pathway

Pyroptosis is a form of proinflammatory gasdermin-mediated programmed cell death. Abnormal mucosal inflammation in the intestine is a critical risk factor for colitis-associated colorectal cancer (CAC). Howeve...

Source: Journal of Hematology and Oncology - November 7, 2020 Category: Hematology Authors: Gao Tan, Chongyang Huang, Jiaye Chen and Fachao Zhi Tags: Rapid communication Source Type: research