Effects of exercise and pharmacological inhibition of histone deacetylases (HDACs) on epigenetic regulations and gene expressions crucial for neuronal plasticity in the motor cortex.

This study showed that HDAC inhibition could present more enriched condition for neuroplasticity to the motor cortex. However, exercise-induced neurotrophic gene expressions could depend on exercise regimen based on the intensity, the term etc. Therefore, this study has a novelty suggesting that pharmacological HDAC inhibition could be an alternative potent approach to present a neuronal platform with enriched neuroplasticity for motor learning and motor recovery, however, an appropriate exercise regimen is expected in this approach.
PMID: 33152341 [PubMed - as supplied by publisher]

Source: Brain Research - November 2, 2020 Category: Neurology Authors: Maejima H, Kitahara M, Takamatsu Y, Mani H, Inoue T Tags: Brain Res Source Type: research