Pharmacological evidence for curcumin neuroprotective effects against lead-stimulated ...

One of the main herbal compounds with neuroprotective effects is curcumin. Lead poisoning cause neurodegeneration effect, however, its mechanism is unclear. The present study assesses the role of Akt/GSK3 signaling pathway in mediating the neuroprotective actions of curcumin against lead-stimulated neurodegeneration. Sixty, adult male, rats were divided in to: Group 1 and 2 received normal saline and drinking water containing 0.075% of lead acetate. Groups 3, 4, 5 and 6 were treated simultaneously with lead acetate (0.075% in drinking water) and I.P. injection of curcumin (10, 20, 40 and 60 mg/kg).Morris water maze (MWM) was used to estimate cognitive activity, Hippocampal oxidative, anti-oxidant, inflammatory and apoptotic factors and also protein kinase B (Akt) and glycogen synthase kinase 3(GSK3) protein levels were studied. We found that lead poisoning disturbed the learning and memory and simultaneous treatment with curcumin reduced the lead -stimulated cognition disorders. Furthermore, treatment with lead acetate triggered an increase in lipid peroxidation and levels of interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), oxidized form of glutathione (GSSG), Bax, GSK3 (total and phosphorylated) while decreasing the reduced form of glutathione (GSH), Bcl-2, and Akt3 (total and phosphorylated) in the hippocampus. Lead also decreased the action of superoxide dismutase (SOD), glutathione peroxidase (GPx) and glutathione reductase (GR) in the hippocamp...
Source: Iranian Journal of Pharmaceutical Research - Category: Drugs & Pharmacology Source Type: research