Comparative genomics of the sequential Pseudomonas aeruginosa isolates obtained from the continuous imipenem stress evolution.

This study aims to clarify the underlying mechanism of imipenem resistance and provide alternative strategies for reducing resistance in P. aeruginosa. KEY POINTS: • Strains with different imipenem MIC were obtained via laboratory selection evolution. • Whole genomes of two strains with different MIC of imipenem were sequenced. • Underlying mechanism of imipenem resistance was clarified via comparative genomics.
PMID: 33151366 [PubMed - as supplied by publisher]

Source: Applied Microbiology and Biotechnology - November 5, 2020 Category: Microbiology Authors: Lu C, Zhou J, Zhang T, Li C, Chen J, Fan J, Qu L, Su X Tags: Appl Microbiol Biotechnol Source Type: research