Metabolic interventions: A new insight into the cancer immunotherapy.

Metabolic interventions: A new insight into the cancer immunotherapy.
Arch Biochem Biophys. 2020 Oct 31;:108659
Authors: Yu T, Dong T, Eyvani H, Fang Y, Wang X, Zhang X, Lu X
Abstract
Metabolic reprogramming confers cancer cells plasticity and viability under harsh conditions. Such active alterations lead to cell metabolic dependency, which can be exploited as an attractive target in development of effective antitumor therapies. Similar to cancer cells, activated T cells also execute global metabolic reprogramming for their proliferation and effector functions when recruited to the tumor microenvironment (TME). However, the high metabolic activity of rapidly proliferating cancer cells can compete for nutrients with immune cells in the TME, and consequently, suppressing their anti-tumor functions. Thus, therapeutic strategies could aim to restore T cell metabolism and anti-tumor responses in TME by targeting the metabolic dependence of cancer cells. In this review, we highlight current research progress on metabolic reprogramming and the interplay between cancer cells and immune cells. We also discuss potential therapeutic intervention strategies for targeting metabolic pathways to improve tumor immunotherapy efficacy.
PMID: 33144083 [PubMed - as supplied by publisher]

Source: Archives of Biochemistry and Biophysics - October 31, 2020 Category: Biochemistry Authors: Yu T, Dong T, Eyvani H, Fang Y, Wang X, Zhang X, Lu X Tags: Arch Biochem Biophys Source Type: research