Phase 1 Study of Low-Dose Fractionated Whole Abdominal Radiation Therapy in Combination With Weekly Paclitaxel for Platinum-Resistant Ovarian Cancer (GCGS-01)

Low-dose fractionated whole abdominal radiation therapy (LDFWART) has synergistic activity with paclitaxel in preclinical models. The aim of this phase 1 trial was to determine the recommended phase 2 dose and preliminary activity of weekly paclitaxel (wP) concurrent with LDFWART in patients with platinum-resistant ovarian cancer (PROC).

Source: International Journal of Radiation Oncology * Biology * Physics - October 8, 2020 Category: Radiology Authors: Natalie Y.L. Ngoi, Valerie Heong, Johann I. Tang, Bok Ai Choo, Nesaretnam Barr Kumarakulasinghe, Diana Lim, Mellisa Low, Siew Eng Lim, Yi Wan Lim, Yiat Horng Leong, Michelle Tseng, Pearl S.Y. Tong, Arunachalam Ilancheran, Jeffrey J.H. Low, Joseph Ng, Yee Tags: Clinical Investigation Source Type: research