Excitatory/Inhibitory Synaptic Ratios in Polymicrogyria and Down Syndrome help explain epileptogenesis in malformations

The ratio between excitatory (glutamatergic) and inhibitory (GABAergic) inputs into maturing individual cortical neurons influences their epileptic potential. Structural factors during development that alter synaptic inputs can be demonstrated neuropathologically. Increased mitochondrial activity identifies neurons with excessive discharge rates.
Source: Pediatric Neurology - Category: Neurology Authors: Tags: Review Article Source Type: research