The antifungal and synergistic effect of bisphosphonates in Cryptococcus.

This study demonstrates the utility of targeting squalene synthesis for improving the efficacy of azole-based antifungal drugs, and suggests bisphosphonates are promising lead compounds for further antifungal development.
PMID: 33139289 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - November 2, 2020 Category: Microbiology Authors: Kane A, Campbell L, Ky D, Hibbs D, Carter D Tags: Antimicrob Agents Chemother Source Type: research