Four gene intrahepatic metastasis –risk signature predicts hepatocellular carcinoma malignant potential and early recurrence from intrahepatic metastasis

Hepatocellular carcinoma has a high recurrence rate even after curative surgery, and hepatocellular carcinoma risk –predictive biomarkers will enable identification of patients who most need close monitoring and cancer-preventive intervention. Hepatocellular carcinoma has 2 different recurrence patterns—a multicentric recurrence and an intrahepatic metastasis. We have reported that the molecular gene signatu re from the gene expression of adjacent liver can be used to predict multicentric recurrence of hepatocellular carcinoma, but the signature to predict recurrence from intrahepatic metastasis has not been established.

Source: Surgery - November 4, 2020 Category: Surgery Authors: Shigeki Nakagawa, Yo-ichi Yamashita, Naoki Umezaki, Takanobu Yamao, Takayoshi Kaida, Yukiharu Hiyoshi, Kosuke Mima, Hirohisa Okabe, Hiromitsu Hayashi, Katsunori Imai, Akira Chikamoto, Hideo Baba Source Type: research