Sensors, Vol. 20, Pages 6289: Optical Biosensors for the Detection of Rheumatoid Arthritis (RA) Biomarkers: A Comprehensive Review
Sensors, Vol. 20, Pages 6289: Optical Biosensors for the Detection of Rheumatoid Arthritis (RA) Biomarkers: A Comprehensive Review
Sensors doi: 10.3390/s20216289
Authors:
José Javier Imas
Carlos Ruiz Zamarreño
Pablo Zubiate
Lorena Sanchez-Martín
Javier Campión
Ignacio Raúl Matías
A comprehensive review of optical biosensors for the detection of biomarkers associated with rheumatoid arthritis (RA) is presented here, including microRNAs (miRNAs), C-reactive protein (CRP), rheumatoid factor (RF), anti-citrullinated protein antibodies (ACPA), interleukin-6 (IL-6) and histidine, which are biomarkers that enable RA detection and/or monitoring. An overview of the different optical biosensors (based on fluorescence, plasmon resonances, interferometry, surface-enhanced Raman spectroscopy (SERS) among other optical techniques) used to detect these biomarkers is given, describing their performance and main characteristics (limit of detection (LOD) and dynamic range), as well as the connection between the respective biomarker and rheumatoid arthritis. It has been observed that the relationship between the corresponding biomarker and rheumatoid arthritis tends to be obviated most of the time when explaining the mechanism of the optical biosensor, which forces the researcher to look for further information about the biomarker. This review work attempts to establish a clear association between optical sensors and rheumatoid arthritis biomarkers as well as to be an ea...
Source: Sensors - Category: Biotechnology Authors: Jos é Javier Imas Carlos Ruiz Zamarre ño Pablo Zubiate Lorena Sanchez-Mart ín Javier Campi ón Ignacio Ra úl Matías Tags: Review Source Type: research