Associations between HOTAIR polymorphisms rs4759314, rs920778, rs1899663, and rs7958904 and risk of primary ovarian insufficiency in Korean women

Primary ovarian insufficiency (POI) is a disease in which ovarian function is lost before the age of 40 [1]. The most common symptoms of POI include amenorrhea and symptoms of estrogen deficiency [2]; however, more than 90% of POI cases are of unknown cause [3,4]. Recent studies indicate that long non-coding RNAs (lncRNAs) are involved in ovarian diseases including POI and polycystic ovary syndrome (PCOS) [5,6]. LncRNAs are non-protein-coding RNA molecules ranging from 200 bp to several kilobases in size [7,13].

Source: Maturitas - November 4, 2020 Category: Primary Care Authors: Sung Hwan Cho, Ji Hyang Kim, Hyun Woo Park, Han Sung Park, Hei Jeong An, Young Ran Kim, Eun Hee Ahn, Woo Sik Lee, Nam Keun Kim Source Type: research