Complement activation and endothelial perturbation parallel COVID-19 severity and activity.

CONCLUSIONS: Complement activation is boosted during the progression of COVID-19 and dampened during remission, thus indicating its role in the pathophysiology of the disease. The association between complement activation and the biomarkers of endothelial damage suggests that complement may contribute to tissue injury and could be the target of specific therapy.
PMID: 33139116 [PubMed - as supplied by publisher]

Source: Journal of Autoimmunity - October 29, 2020 Category: Allergy & Immunology Authors: Cugno M, Meroni PL, Gualtierotti R, Griffini S, Grovetti E, Torri A, Lonati P, Grossi C, Borghi MO, Novembrino C, Boscolo M, Uceda Renteria SC, Valenti L, Lamorte G, Manunta M, Prati D, Pesenti A, Blasi F, Costantino G, Gori A, Bandera A, Tedesco F, Peyva Tags: J Autoimmun Source Type: research