Preclinical Models to Study Obesity and Breast Cancer in Females: Considerations, Caveats, and Tools

We describe relevant mouse and rat paradigms, specifically highlighting differences in breast tumor subtypes, estrogen production, and strategies to manipulate hormone levels. We also outline options for diet composition and housing environments to promote obesity in female rodents. While we have applied our experience to understanding obesity-associated breast cancer, the experimental variables we incorporate have relevance to multiple fields that investigate women ’s health.
Source: Journal of Mammary Gland Biology and Neoplasia - Category: Cancer & Oncology Source Type: research