Bcl2 like protine-12 (Bcl2L12) facilitates experimental airway allergic inflammation by inducing autocrine eotaxin in eosinophils.

CONCLUSIONS: AAD Eos express high levels of Bcl2L12, the latter is associated with AAD response by regulating the autocrine eotaxin 1 in Eos. Depletion of Bcl2L12 in Eos attenuates experimental AAD, suggesting that to suppress the Bcl2L12 Eos has the translational potential in the treatment of AAD.
PMID: 33132183 [PubMed - as supplied by publisher]

Source: Immunology Letters - October 24, 2020 Category: Allergy & Immunology Authors: Yang G, Liu JQ, Mo LH, Luo XQ, Li J, Liu ZQ, Liu DB, Liu ZG, Yang PC, Shi JB Tags: Immunol Lett Source Type: research