Skp2 regulates DNA damage repair and apoptosis via interaction with Ku70.

CONCLUSION: The direct interaction between Skp2 and Ku70 proteins mediates the DNA damage repair and cellular apoptosis by regulating Ku70 stability and function via post-translational modification. The molecular mechanisms how Skp2 stabilize Ku70 would be clarified in our following research work.
PMID: 33132134 [PubMed - as supplied by publisher]

Source: Experimental Cell Research - October 22, 2020 Category: Cytology Authors: Jia J, Yan D, Wang Y, Liu M, Jia Z, Luo L, Ren J, Fang J, Yuan H, Zhao Y, Song Y, He Y, Wang X Tags: Exp Cell Res Source Type: research