Altered Functional Integration in the Salience and Default Mode Networks in Euthymic Pediatric Bipolar Disorder.

In this study, 16 euthymic PBD patients and 16 healthy controls underwent resting-state functional magnetic resonance imaging. A data-driven functional connectivity analysis was used to investigate functional connectivity changes of the euthymic PBD. Compared with healthy controls, the euthymic PBD exhibited greater global functional connectivity density in the left anterior insula and lower global functional connectivity density in the right temporoparietal junction, the left angular gyrus, and the bilateral occipital lobule. A distant functional connectivity analysis demonstrated altered integration within the salience and default mode networks in euthymic PBD. Correlation analysis found that altered functional connectivity of the salience network was related to the reduced performance in the backward digit span test, and altered functional connectivity of the default mode network was related to the Young Mania Rating Scale in euthymic PBD patients. Our findings indicated that disturbed functional integration in salience and default mode networks might shed light on the physiopathology associated with emotional and cognitive dysregulation in PBD.
PMID: 33133177 [PubMed - in process]

Source: Neural Plasticity - November 3, 2020 Category: Neurology Authors: Cao W, Chen H, Jiao Q, Cui D, Guo Y, Gao W, Qiu J, Su L, Lu G Tags: Neural Plast Source Type: research