Cysteinyl leukotriene D 4 (LTD 4 ) promotes airway epithelial cell inflammation and remodelling

ConclusionThe results suggest that LTD4 could induce inflammatory response in human airway epithelial cell by activating NALP3 inflammasome. LTD4 could further promote airway epithelial cells ’ remodelling through TGF-β/smad2/3-mediated pathway. Our in vivo results suggested that obesity predisposed the OVA challenged mice to develop lung inflammation and remodelling akin to asthma-like phenotypes during obesity.
Source: Inflammation Research - Category: Research Source Type: research