Non-invasive imaging prediction of tumor hypoxia: a novel developed and externally validated CT and FDG-PET-based radiomic signatures

Since the early 1930s, it has been established that solid tumors contain oxygen-deficient (hypoxic) areas. Cells in such areas may cause tumors to become resistant to radiotherapy and chemotherapy, increase tumor aggressiveness, angiogenesis, and metastatic spread, resulting in a poor prognosis [1 –4].

Source: Radiotherapy and Oncology - October 30, 2020 Category: Radiology Authors: Sebastian Sanduleanu, Arthur Jochems, Taman Upadhaya T, Aniek J.G. Even, Ralph T.H. Leijenaar, Frank J.W.M. Dankers, Remy Klaassen, Henry C. Woodruff, Matthieu Hatt, Hans J.A.M. Kaanders, Olga Hamming-Vrieze, Hanneke W.M. van Laarhoven H, Rathan M. Subram Tags: Original Article Source Type: research