TRIP13 promotes the proliferation and invasion of lung cancer cells via the Wnt signaling pathway and epithelial –mesenchymal transition

This study found that TRIP13 can co-localize and bind with LRP6. Furthermore, overexpression of TRIP13 caused the upregulation of N-cadherin, Snail, and vimentin, and the downregulation of E-cadherin (p <  0.05). The aforementioned results were reversed after knocking down the expression of TRIP13 (p <  0.05). TRIP13 is highly expressed in lung cancers, indicating poor prognosis. overexpression of TRIP13 promotes the proliferative and invasive ability of lung cancer cells via the activation of Wnt signaling pathway and EMT.
Source: Journal of Molecular Histology - Category: Laboratory Medicine Source Type: research