Identification of Functional Genetic Variants Associated with Alcohol Dependence and Related Phenotypes Using a High-Throughput Assay.

CONCLUSION: The SNPs identified in the PASSPORT-seq assay are functional variants that might affect the risk for AD and related phenotypes. Our study provides insights into gene regulation in AD and demonstrates the value of PASSPORT-seq as a tool to screen genetic variants in GWAS loci for one potential mechanism of action. PMID: 33119910 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33119910?dopt=Abstract

Source: Alcoholism, Clinical and Experimental Research - October 29, 2020 Category: Addiction Authors: Thapa KS, Chen AB, Lai D, Xuei X, Wetherill L, Tischfield JA, Liu Y, Edenberg HJ Tags: Alcohol Clin Exp Res Source Type: research