Differentially altered social dominance- and cooperative-like behaviors in Shank2 - and Shank3 -mutant mice

ConclusionsOur results underscore the heterogeneity of social behavioral alterations in different ASD mouse models and highlight the utility of testing complex social behaviors in validating neurodevelopmental and neuropsychiatric disorder models. In addition, neural activities at distinct brain regions are likely collectively involved in eliciting complex social behaviors, which are differentially altered in ASD mouse models.
Source: Molecular Autism - Category: Molecular Biology Source Type: research