Breath acetone change during aerobic exercise is moderated by cardiorespiratory fitness
Exhaled breath acetone (BrAce) was investigated during and after submaximal aerobic exercise as a
volatile biomarker for metabolic responsiveness in high and lower-fit individuals in a prospective
cohort pilot-study. Twenty healthy adults (19 –39 years) with different levels of cardiorespiratory
fitness (VO 2peak ), determined by spiroergometry, were recruited. BrAce was repeatedly measured by
proton-transfer-reaction time-of-flight mass spectrometry (PTR-TOF-MS) during 40 –55 min submaximal
cycling exercise and a post-exercise period of 180 min. Activity of ketone and fat metabolism during
and after exercise were assessed by indirect calorimetric calculation of fat oxidation rate and by
measurement of venous β-hydroxybutyrate (βHB). Maximum BrAce ratios were significantly higher during
exercise in the high-fit individuals compared to the lower-fit group (t-test; p = 0.03).
Multivariate regression showed 0.4% (95%-CI = −0.2%–0.9%, p = 0.155) higher BrAce chang...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Karsten K önigstein, Sebastian Abegg, Andrea N Schorn, Ines C Weber, Nina Derron, Andreas Krebs, Philipp A Gerber, Arno Schmidt-Trucksäss and Andreas T Güntner Source Type: research