Towards homogenization of total body irradiation practices in pediatric patients across SIOPE affiliated centers a survey by the SIOPE radiation oncology working group

Chemotherapy cures most children with hematologic malignancies. However, some 15% of all children with acute leukemia (acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML)) and high risk features or relapse, benefit from donor (allogeneic) hematopoietic stem cell transplantation (HSCT) [1]. HSCT for hematologic malignancies is usually preceded by a conditioning regimen with myeloablative doses of chemotherapy (mostly treosulfan or busulphan-based) or with Total Body Irradiation (TBI), often combined with etoposide or cyclophosphamide [1].

Source: Radiotherapy and Oncology - October 30, 2020 Category: Radiology Authors: Bianca A.W. Hoeben, Montserrat Pazos, Michael H. Albert, Enrica Seravalli, Mirjam E. Bosman, Christoph Losert, Tom Boterberg, Farkhad Manapov, Inna Ospovat, Soraya Mico Milla, Candan Demiroz Abakay, Jacob Engellau, Gregor Kos, St éphane Supiot, Marc Bier Tags: Original Article Source Type: research