MALDI-ToF Mass spectra phenomic analysis for human disease diagnosis enabled by cutting-edge data processing pipelines and bioinformatic tools.

MALDI-ToF Mass spectra phenomic analysis for human disease diagnosis enabled by cutting-edge data processing pipelines and bioinformatic tools. Curr Med Chem. 2020 Oct 27;: Authors: Pais RJ, Iles RK, Zmuidinaite R Abstract Currently, methodologies of human disease diagnosis are still far from capable of rapidly and accurately screening for multiple diseases, simultaneously in a large population, at affordable costs. MALDI-ToF mass spectrometry is an ultra-sensitive, ultra-fast and low-cost high-throughput technology which has a huge potential in clinical laboratory medicine to achieve this goal. Such clinical analysis is starting the first steps towards human phenotype detection and hence phenomic screening for multiple disease states. In this review, we will discuss the main advances achieved so far; putting forward targeted applications of MALDI-ToF mass spectrometry in the service of human disease detection. Here, we will focus mostly on methodological workflow, namely MALDI-ToF data processing for phenomic analysis, using state-of-the-art bioinformatic pipelines and software tools. We will further focus on the role of mathematical modelling, machine learning and artificial intelligence algorithms for disease screening. Moreover, we will present some already developed tools for disease diagnostics and screening based on MALDI-ToF analysis. We will discuss the remaining challenges that are ahead when implementing MALDI-ToF into cli...
Source: Current Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Med Chem Source Type: research